Raloxifene Impurity 4

Name	2-(4-Hydroxyphenyl)-benzo[b]thiophene-6-ol
Synonyms	Raloxifene Impurity 4 Raloxifene InterMediate 2-(4-Hydroxyphenyl)benzothiophene-6-ol 2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol 2-(4-hydroxyphenyl)-1-benzothiophen-6-ol 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol 2-(4-hydroxyphenyl)-1-benzothiophene-6-ol 2-(4-Hydroxyphenyl)-benzo[b]thiophene-6-ol 6-Hydroxy-2-(4-Hydroxyphenyl)Benzo[B]Thiophene
CAS	63676-22-2

Molecular Formula	C14H10O2S
Molar Mass	242.29
Density	1.383
Melting Point	295 °C(dec.)
Boling Point	477.0±30.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Pale Grey
pKa	9.32±0.15(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Last Update：2024-01-02 23:10:35

biological activity	eprogen receptor modulator 1 (compound 18) is an orally active selective eprogen receptor modulator (SERM), the pIC50 value was 0.46. Eprogen receptor modulator 1 has potential anti-tumor activity.
Target	Value
ER (Cell-free assay)	0.46(pIC50)
Cell Line:	T47D:A18/PKCα and T47D:A18-TAM1 cells MCF-7:5C cells
Concentration:	100 nM 100 nM
Incubation Time:	10 days 9 days
Result:	Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Significantly inhibited the growth of MCF-7:5C cells. Significantly reduced tumor volume.
Animal Model:	4-6 week old athymic mice (Harlan-Sprague-Dawley)
Dosage:	1.5 mg/animal
Administration:	p.o. ; daily for 2 weeks

Last Update：2024-04-09 19:05:13

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CAS: 63676-22-2
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